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KMID : 0371020070400020095
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Journal of Preventive Medicine and Public Health
2007 Volume.40 No. 2 p.95 ~ p.101
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Strategy Considerations in Genome Cohort Construction in Korea
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Sung Joo-hon
Cho Sung-il
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Abstract
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Focusing on complex diseases of public health significance, strategic issues regarding the on-going Korean Genome Cohort were reviewed: target size and diseases, measurements, study design issues, and followup strategy of the cohort. Considering the epidemiologic characteristics of Korean population as well as strengths and drawbacks of current research environment, we tried to tailor the experience of other existing cohorts into proposals for this Korean study. Currently 100,000 individuals have been participating the new Genome Cohort in Korea. Target size of de novo collection is recommended to be set as between 300,000 to 500,000. This target size would allow acceptable power to detect genetic and environmental factors of moderate effect size and possible interactions between them. Family units and/or special subgroups are recommended to parallel main body of adult Given that response rate to the conventional re-contact method may not be satisfactory, successful follow-up is the main key to the achievement of the Korean Genome Cohort. Access to the central database such as National Health Insurance data can provide enormous potential for near-complete case detection. Efforts to build consensus amongst scientists from broad fields and stakeholders are crucial to unleash the centralized database as well as to refine the commitment of this national project.
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KEYWORD
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Cohort studies, Human genome, Genetic predisposition to disease, National Health Insurance, Republic of Korea, Follow-up studies, Biological specimen banks
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